Parallel Human and Animal Models of Blast- and Concussion-Induced Tinnitus and Related Traumatic Brain Injury (TBI)

In the second year, we continued our work concerning blast- or concussion-induced traumatic brain injury (TBI) that is often associated with tinnitus. In animal studies, we conducted behavioral testing of tinnitus, anxiety and spatial cognition, MRI-DTI and MEMRI imaging, and electrophysiology in the dorsal cochlear nucleus (DCN), inferior colliculus (IC) and auditory cortex (AC), and histological assays. We found that blast-induced tinnitus …