Prospective Evaluation of An Argatroban Dosing Nomogram Using the Ecarin Chromogenic Assay at a Tertiary Institution

Abstract There is a lack of consensus on how to best monitor therapy with the direct thrombin inhibitor argatroban. Currently, the most commonly used test is the activated partial thromboplastin time (aPTT). However, it has limited reliability, as it is easily affected by other factors, and the target is unclear in patients whose baseline values are abnormal. The ecarin chromogenic assay (ECA) reaction time is strongly …