Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review

INTRODUCTION: Paracetamol is the most commonly used antipyretic and analgesic in pregnancy. It is also increasingly used off-label in the neonatal intensive care unit. Despite the frequent use of paracetamol, concerns have been raised regarding the high variability in neonatal dosing regimens and the long-term safety of early life exposure. OBJECTIVE: To investigate the available evidence on the long-term safety of prenatal and neonatal …