Journal article
Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis
Abstract
BACKGROUND: Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use on cancer risk. Naturally occurring variation in genes encoding antihypertensive drug targets can be used as proxies for these targets to examine the effect of their long-term therapeutic inhibition on disease outcomes.
METHODS AND FINDINGS: We performed a mendelian randomization analysis to …
Authors
Yarmolinsky J; Díez-Obrero V; Richardson TG; Pigeyre M; Sjaarda J; Paré G; Walker VM; Vincent EE; Tan VY; Obón-Santacana M
Journal
PLOS Medicine, Vol. 19, No. 2,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pmed.1003897
ISSN
1549-1277