Journal article
Diazoxide, a KATP Channel Opener, Prevents Ischemia–Reperfusion Injury in Rodent Pancreatic Islets
Abstract
Diazoxide (DZ) is a pharmacological opener of ATP-sensitive K(+) channels that has been used for mimicking ischemic preconditioning and shows protection against ischemic damage. Here we investigated whether diazoxide supplementation to University of Wisconsin (UW) solution has cellular protection during islet isolation and improves in vivo islet transplant outcomes in a rodent ischemia model. C57/B6 mice pancreata were flushed with UW or UW + …
Authors
Wang Y; Wang S; Harvat T; Kinzer K; Zhang L; Feng F; Qi M; Oberholzer J
Journal
Cell Transplantation, Vol. 24, No. 1, pp. 25–36
Publisher
SAGE Publications
Publication Date
January 2015
DOI
10.3727/096368913x673441
ISSN
0963-6897