Journal article
Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts
Abstract
Crohn’s disease is an inflammatory disease of the gastrointestinal tract characterized by an aberrant response to microbial and environmental triggers. This includes an altered microbiome dominated by Enterobacteriaceae and in particular adherent-invasive E. coli (AIEC). Clinical evidence implicates periods of psychological stress in Crohn’s disease exacerbation, and disturbances in the gut microbiome might contribute to the pathogenic …
Authors
Shaler CR; Parco AA; Elhenawy W; Dourka J; Jury J; Verdu EF; Coombes BK
Journal
Nature Communications, Vol. 12, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-021-26992-4
ISSN
2041-1723