Journal article
23.4 PET-BASED PRECISION NEUROIMAGING OF THE ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR IN PATIENTS WITH RECENT ONSET OF PSYCHOSIS
Abstract
Low availability of the α7 nicotinic acetylcholine receptor (α7-nAChR) in the hippocampus of patients with schizophrenia has been suggested from study of postmortem tissue, and therapies that increase signaling through the α7-nAChR may ameliorate signs and symptoms of psychosis, including associated cognitive deficits. Here we used [18F]ASEM with positron emission tomography (PET) to test for hypothesized low in vivo availability of the …
Authors
Coughlin J; Du Y; Crawford J; Rubin L; Azad BB; Lesniak WL; Horti A; Schretlen D; Sawa A; Pomper M
Journal
Schizophrenia Bulletin, Vol. 45, No. Supplement_2, pp. s127–s127
Publisher
Oxford University Press (OUP)
Publication Date
April 9, 2019
DOI
10.1093/schbul/sbz022.094
ISSN
0586-7614