Halothane-induced rigidity and associated glycolytic and energy phosphate changes in red and white fibres of skeletal muscle of the pig

The exposure of a group of Piètrain pigs to halothane at the levels required to induce anaesthesia initiated muscular rigidity and hyperthermia in all individuals of the group whereas a group of Irish Landrace pigs did not respond adversely to the anaesthetic. The speed at which rigidity developed in the halothane sensitive animals was a remarkable feature of the syndrome. Biochemically, the condition was characterized by depletion of energy …