A Prospective Cohort Study of the Epidemiology of Symptomatic Venous Thromboembolism (VTE) after Isolated Leg Fractures Distal to the Knee without Thromboprophylaxis.

Abstract We report final results from the first, large, multicenter, prospective cohort study designed to define the incidence of symptomatic venous thromboembolism (VTE) in patients with isolated leg fractures below the knee, and determine if routine thromboprophylaxis will be cost-effective. The reported incidence of deep vein thrombosis (DVT) using screening venography in such patients is as high as 40%. This has lead to …