Meta-analysis of Pragmatic and Explanatory Trials

Pooling studies with different clinical and methodological features may lead to statistical heterogeneity, particularly if heterogeneity remains unexplained. One potential source of heterogeneity may be how much the included trials tend toward a pragmatic or explanatory design. Many tools have been developed to aid researchers in quantifying pragmatism in clinical trials, at both the design and appraisal stages.In this chapter we review these …