Journal article
Effect of centrally and peripherally acting GABAB agonism on the healthy human cough reflex
Abstract
BACKGROUND: Currently there are no effective licensed anti-tussive therapies. Understanding how the neuronal mechanisms mediating the cough reflex in animal models translate to humans is important for the development of effective therapies. Pre-clinical studies suggest that the activation of GABAB receptors in both the peripheral and central nervous systems inhibit cough.
OBJECTIVE: To compare the effect of central and peripherally acting GABAB …
Authors
Badri H; LGibbard C; Denton D; Satia I; Dockry RJ; Holt K; Escott J; Wilkinson G; Holt A; Canning BJ
Journal
Pulmonary Pharmacology & Therapeutics, Vol. 71, ,
Publisher
Elsevier
Publication Date
12 2021
DOI
10.1016/j.pupt.2021.102079
ISSN
1094-5539