Journal article
Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)
Abstract
Microbial natural products are an invaluable source of evolved bioactive small molecules and pharmaceutical agents. Next-generation and metagenomic sequencing indicates untapped genomic potential, yet high rediscovery rates of known metabolites increasingly frustrate conventional natural product screening programs. New methods to connect biosynthetic gene clusters to novel chemical scaffolds are therefore critical to enable the targeted …
Authors
Skinnider MA; Dejong CA; Rees PN; Johnston CW; Li H; Webster ALH; Wyatt MA; Magarvey NA
Journal
Nucleic Acids Research, Vol. 43, No. 20, pp. 9645–9662
Publisher
Oxford University Press (OUP)
Publication Date
November 16, 2015
DOI
10.1093/nar/gkv1012
ISSN
0305-1048