Journal article
Investigating β-Hydroxyenduracididine Formation in the Biosynthesis of the Mannopeptimycins
Abstract
The mannopeptimycins (MPPs) are potent glycopeptide antibiotics that contain both D and L forms of the unique, arginine-derived amino acid beta-hydroxyenduracididine (betahEnd). The product of the mppO gene in the MPP biosynthetic cluster resembles several non-heme iron, alpha-ketoglutarate-dependent oxygenases, such as VioC and clavaminate synthase. The role of MppO in betahEnd biosynthesis was confirmed through inactivation of mppO, which …
Authors
Haltli B; Tan Y; Magarvey NA; Wagenaar M; Yin X; Greenstein M; Hucul JA; Zabriskie TM
Journal
Cell Chemical Biology, Vol. 12, No. 11, pp. 1163–1168
Publisher
Elsevier
Publication Date
11 2005
DOI
10.1016/j.chembiol.2005.09.013
ISSN
2451-9456