Journal article
Gatekeeping versus Promiscuity in the Early Stages of the Andrimid Biosynthetic Assembly Line
Abstract
The antibiotic andrimid, a nanomolar inhibitor of bacterial acetyl coenzyme A carboxylase, is generated on an unusual polyketide/nonribosomal peptide enzyme assembly line in that all thiolation (T) domains/small-molecule building stations are on separate proteins. In addition, a transglutaminase homologue is used to condense andrimid building blocks together on the andrimid assembly line. The first two modules of the andrimid assembly line …
Authors
Magarvey NA; Fortin PD; Thomas PM; Kelleher NL; Walsh CT
Journal
ACS Chemical Biology, Vol. 3, No. 9, pp. 542–554
Publisher
American Chemical Society (ACS)
Publication Date
September 19, 2008
DOI
10.1021/cb800085g
ISSN
1554-8929