Journal article
Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease
Abstract
Diabetic kidney disease (DKD) is caused by the overproduction of extracellular matrix proteins (ECM) by glomerular mesangial cells (MCs). We previously showed that high glucose (HG) induces cell surface translocation of GRP78 (csGRP78), mediating PI3K/Akt activation and downstream ECM production. Activated alpha 2-macroglobulin (α2M*) is a ligand known to initiate this signaling cascade. Importantly, increased α2M was observed in diabetic …
Authors
Trink J; Li R; Palarasah Y; Troyanov S; Andersen TE; Sidelmann JJ; Inman MD; Pizzo SV; Gao B; Krepinsky JC
Journal
Biomedicines, Vol. 9, No. 9,
Publisher
MDPI
DOI
10.3390/biomedicines9091112
ISSN
2227-9059