Journal article
Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis
Abstract
No approved therapies are available for nonalcoholic steatohepatitis (NASH). Adenosine monophosphate-activated protein kinase (AMPK) is a central regulator of cell metabolism; its activation has been suggested as a therapeutic approach to NASH. Here we aimed to fully characterize the potential for direct AMPK activation in preclinical models and to determine mechanisms that could contribute to efficacy for this disease. A novel small-molecule …
Authors
Gluais‐Dagorn P; Foretz M; Steinberg GR; Batchuluun B; Zawistowska‐Deniziak A; Lambooij JM; Guigas B; Carling D; Monternier P; Moller DE
Journal
Hepatology Communications, Vol. 6, No. 1, pp. 101–119
Publisher
Wolters Kluwer
Publication Date
January 2022
DOI
10.1002/hep4.1799
ISSN
2471-254X