Journal article
Randomized Trials Stopped Early for Benefit: A Systematic Review
Abstract
CONTEXT: Randomized clinical trials (RCTs) that stop earlier than planned because of apparent benefit often receive great attention and affect clinical practice. Their prevalence, the magnitude and plausibility of their treatment effects, and the extent to which they report information about how investigators decided to stop early are, however, unknown.
OBJECTIVE: To evaluate the epidemiology and reporting quality of RCTs involving …
Authors
Montori VM; Devereaux PJ; Adhikari NKJ; Burns KEA; Eggert CH; Briel M; Lacchetti C; Leung TW; Darling E; Bryant DM
Journal
JAMA: The Journal of the American Medical Association, Vol. 294, No. 17, pp. 2203–2209
Publisher
American Medical Association (AMA)
Publication Date
November 2, 2005
DOI
10.1001/jama.294.17.2203
ISSN
0098-7484