Clonidine in the sedation of mechanically ventilated children: A pilot randomized trial

PURPOSE: Clonidine is often used as a sedative in critically ill children, but its effectiveness has not been evaluated in a large, rigorous randomized controlled trial. Our objectives in this pilot trial were to assess the feasibility of a larger trial with respect to (1) effective screening, (2) recruitment, (3) timely drug administration, and (4) protocol adherence. MATERIALS AND METHODS: This is a randomized, blinded, placebo-controlled …