Journal article
Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System
Abstract
A screen for agents that potentiated the activity of paromomycin (PAR), a 4,5-linked aminoglycoside (AG), against wild-type Pseudomonas aeruginosa identified the RNA polymerase inhibitor rifampin (RIF). RIF potentiated additional 4,5-linked AGs, such as neomycin and ribostamycin, but not the clinically important 4,6-linked AGs amikacin and gentamicin. Potentiation was absent in a mutant lacking the AmgRS envelope stress response two-component …
Authors
Poole K; Gilmour C; Farha MA; Mullen E; Lau CH-F; Brown ED
Journal
Antimicrobial Agents and Chemotherapy, Vol. 60, No. 6, pp. 3509–3518
Publisher
American Society for Microbiology
Publication Date
June 2016
DOI
10.1128/aac.03069-15
ISSN
0066-4804
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AmikacinAnti-Bacterial AgentsBacterial ProteinsDrug Resistance, Multiple, BacterialDrug SynergismGene Expression Regulation, BacterialGentamicinsHeat-Shock ProteinsHumansMembrane ProteinsMicrobial Sensitivity TestsParomomycinPseudomonas InfectionsPseudomonas aeruginosaRibostamycinRifampinStress, Physiological