Journal article
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis
Abstract
In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control …
Authors
Loley C; Alver M; Assimes TL; Bjonnes A; Goel A; Gustafsson S; Hernesniemi J; Hopewell JC; Kanoni S; Kleber ME
Journal
Scientific Reports, Vol. 6, No. 1,
Publisher
Springer Nature
DOI
10.1038/srep35278
ISSN
2045-2322