Journal article
G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9
Abstract
Certain chemokines possess anti-angiogenic and antibacterial activity, in addition to their ability to recruit leukocytes. Herein, we demonstrate that CXCL9/MIG induces the expression, by a monocytic cell line and peripheral blood mononuclear cells, of a variety of chemokines including CXCL8/IL-8, CCL3/MIP-1alpha, CCL4/MIP-1beta, CCL2/MCP-1 in a pertussis toxin insensitive manner. Similarly, another cationic chemokine CCL20/MIP-3alpha, but not …
Authors
Gong J-H; Nicholls EF; Elliott MR; Brown KL; Hokamp K; Roche FM; Cheung CYK; Falsafi R; Brinkman FSL; Bowdish DME
Journal
Cellular Immunology, Vol. 261, No. 2, pp. 105–113
Publisher
Elsevier
Publication Date
2010
DOI
10.1016/j.cellimm.2009.11.007
ISSN
0008-8749
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Cell LineChemokine CCL2Chemokine CCL20Chemokine CXCL9Chemotaxis, LeukocyteEnzyme ActivationExtracellular Signal-Regulated MAP KinasesGene Expression RegulationHumansImmunologic FactorsLeukocytes, MononuclearMicroarray AnalysisMolecular Sequence DataMonocytesPertussis ToxinReceptors, CCRReceptors, G-Protein-Coupledp38 Mitogen-Activated Protein Kinases