Journal article
A Pan-Canadian Validation Study for the Detection of EGFR T790M Mutation Using Circulating Tumor DNA From Peripheral Blood
Abstract
INTRODUCTION: Genotyping circulating tumor DNA (ctDNA) is a promising noninvasive clinical tool to identify the EGFR T790M resistance mutation in patients with advanced NSCLC with resistance to EGFR inhibitors. To facilitate standardization and clinical adoption of ctDNA testing across Canada, we developed a 2-phase multicenter study to standardize T790M mutation detection using plasma ctDNA testing.
METHODS: In phase 1, commercial reference …
Authors
Selvarajah S; Plante S; Speevak M; Vaags A; Hamelinck D; Butcher M; McCready E; Grafodatskaya D; Blais N; Tran-Thanh D
Journal
JTO Clinical and Research Reports, Vol. 2, No. 8,
Publisher
Elsevier
Publication Date
August 2021
DOI
10.1016/j.jtocrr.2021.100212
ISSN
2666-3643