Journal article
Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy
Abstract
OBJECTIVE: Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signalling by cells of the myeloid-lineage. Here, we aimed to understand the contribution of activated microglia located in vulnerable brain regions (e.g. frontal, subcortical) of HIV-infected, virally suppressed (HIV+VS) individuals in relation to cognitive and motor function.
DESIGN: Twenty-one HIV+VS individuals …
Authors
Rubin LH; Sacktor N; Creighton J; Du Y; Endres CJ; Pomper MG; Coughlin JM
Journal
AIDS, Vol. 32, No. 12, pp. 1661–1667
Publisher
Wolters Kluwer
Publication Date
July 31, 2018
DOI
10.1097/qad.0000000000001858
ISSN
0269-9370