Journal article
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions
Abstract
Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm). Correlations between Pv and Pm were …
Authors
Shungin D; Deng WQ; Varga TV; Luan J; Mihailov E; Metspalu A; Morris AP; Forouhi NG; Lindgren C; Magnusson PKE
Journal
PLOS Genetics, Vol. 13, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pgen.1006812
ISSN
1553-7390