Journal article
Development of primary and secondary immune responses to mouse monoclonal antibodies used in the diagnosis and therapy of malignant neoplasms.
Abstract
Human anti-mouse immunoglobulin immune responses were studied in ten patients, eight with ovarian cancer and two with grade IV gliomas, diagnosed and treated with radiolabeled (123I, 131I) murine monoclonal antibodies. It was found that serum from these patients before treatment and from 18 control healthy individuals contained detectable antibodies to antigenic determinants on the Fc but not the F(ab')2 portion of mouse immunoglobulin. No …
Authors
Courtenay-Luck NS; Epenetos AA; Moore R; Larche M; Pectasides D; Dhokia B; Ritter MA
Journal
Cancer Research, Vol. 46, No. 12 Pt 1, pp. 6489–6493
Publication Date
12 1986
ISSN
0008-5472