Journal article
A newly discovered class of human hematopoietic cells with SCID-repopulating activity
Abstract
The detection of primitive hematopoietic cells based on repopulation of immune-deficient mice is a powerful tool to characterize the human stem-cell compartment. Here, we identify a newly discovered human repopulating cell, distinct from previously identified repopulating cells, that initiates multilineage hematopoiesis in NOD/SCID mice. We call such cells CD34neg- SCID repopulating cells, or CD34neg-SRC. CD34neg-SRC are restricted to a …
Authors
Bhatia M; Bonnet D; Murdoch B; Gan OI; Dick JE
Journal
Nature Medicine, Vol. 4, No. 9, pp. 1038–1045
Publisher
Springer Nature
Publication Date
9 1998
DOI
10.1038/2023
ISSN
1078-8956