Journal article
The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression
Abstract
The chemokine stromal derived factor-1alpha (SDF-1alpha) has been implicated recently in the chemotaxis of primitive human hematopoietic cells, suggesting that pluripotent human stem cells express the SDF-1alpha receptor, CXCR4. By using flow cytometry and confocal microscopy, we have identified and isolated primitive subsets of human CXCR4(+) and CXCR4(-) cells. Distinctions in the progenitor content and response to SDF-1alpha in vitro …
Authors
Rosu-Myles M; Gallacher L; Murdoch B; Hess DA; Keeney M; Kelvin D; Dale L; Ferguson SSG; Wu D; Fellows F
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 26, pp. 14626–14631
Publisher
Proceedings of the National Academy of Sciences
Publication Date
December 19, 2000
DOI
10.1073/pnas.97.26.14626
ISSN
0027-8424