Journal article
The Histone Demethylase KDM5b/JARID1b Plays a Role in Cell Fate Decisions by Blocking Terminal Differentiation
Abstract
The histone demethylase lysine demethylase 5b (KDM5b) specifically demethylates lysine 4 of histone H3 (meH3K4), thereby repressing gene transcription. KDM5b regulates cell cycle control genes in cancer and is expressed in the early epiblast. This suggests that KDM5b plays a developmental role by maintaining uncommitted progenitors. Here we show that transient overexpression of KDM5b in embryonic stem cells decreases the expression of at least …
Authors
Dey BK; Stalker L; Schnerch A; Bhatia M; Taylor-Papidimitriou J; Wynder C
Journal
Molecular and Cellular Biology, Vol. 28, No. 17, pp. 5312–5327
Publisher
Taylor & Francis
Publication Date
September 1, 2008
DOI
10.1128/mcb.00128-08
ISSN
0270-7306
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBiomarkersCell DifferentiationCell LineCell LineageCell ProliferationDNA-Binding ProteinsEmbryonic Stem CellsHistonesHomeodomain ProteinsJumonji Domain-Containing Histone DemethylasesLysineMiceModels, BiologicalNanog Homeobox ProteinNeoplasm ProteinsNeuronsOxidoreductases, N-DemethylatingRepressor ProteinsTCF Transcription FactorsTranscription Factor 7-Like 1 ProteinTranscription, Genetic