Journal article
Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity
Abstract
The clinical applicability of direct cell fate conversion depends on obtaining tissue from patients that is easy to harvest, store, and manipulate for reprogramming. Here, we generate induced neural progenitor cells (iNPCs) from neonatal and adult peripheral blood using single-factor OCT4 reprogramming. Unlike fibroblasts that share molecular hallmarks of neural crest, OCT4 reprogramming of blood was facilitated by SMAD+GSK-3 inhibition to …
Authors
Lee J-H; Mitchell RR; McNicol JD; Shapovalova Z; Laronde S; Tanasijevic B; Milsom C; Casado F; Fiebig-Comyn A; Collins TJ
Journal
Cell Reports, Vol. 11, No. 9, pp. 1367–1376
Publisher
Elsevier
Publication Date
June 2015
DOI
10.1016/j.celrep.2015.04.056
ISSN
2639-1856