Journal article
A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge
Abstract
Recombinant influenza virus vaccines based on hemagglutinin (HA) hold the potential to accelerate production timelines and improve efficacy relative to traditional egg-based platforms. Here, we assess a vaccine adjuvant system comprised of immunogenic liposomes that spontaneously convert soluble antigens into a particle format, displayed on the bilayer surface. When trimeric H3 HA was presented on liposomes, antigen delivery to macrophages was …
Authors
Sia ZR; He X; Zhang A; Ang JC; Shao S; Seffouh A; Huang W-C; D'Agostino MR; Teimouri Dereshgi A; Suryaprakash S
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 22,
Publisher
Proceedings of the National Academy of Sciences
Publication Date
6 2021
DOI
10.1073/pnas.2025759118
ISSN
0027-8424