Chapter 22 Downregulation of the Raf kinase inhibitory protein (RKIP) in clear cell renal cell carcinoma associates with poor prognosis

Clear cell renal cell carcinoma (ccRCC) is the major cause of kidney cancer death. Downregulation of the Raf kinase inhibitory protein (RKIP) tumor suppressor likely contributes to ccRCC progression and fatality; however, this possibility has not been thoroughly examined. By analyzing publically available ccRCC datasets (TCGA and others), we report here a robust association of RKIP downregulation with ccRCC progression. Reductions in RKIP mRNA …