Chapter 6 Chronic Progressive External Ophthalmoplegia (CPEO)

A 55-year-old man was referred to our clinic for assessment of treatment-resistant myasthenia gravis. He presented to a community neurologist one year prior with a two-month history of ptosis and diplopia worse at the end of the day. Neurological examination showed a normal mental status, cranial nerve examination was positive for right greater than left ptosis, and ophthalmoparesis was limited to ∼15° in all directions with the up-gaze being …