Journal article
A293 SQUALAMINE INCREASES VAGAL AFFERENT FIRING FREQUENCY IN AGING MICE
Abstract
A large portion of the aging population exhibit comorbid gastrointestinal (GI) disorders and common age-related neurodegenerative conditions often including constipation, sleep disturbance, and depression. Luminal gut contents and microbiota have the ability to influence mood and behaviour through the vagal gut-brain axis. Squalamine, an aminosterol originally isolated from the dogfish shark, is a potent stimulator of the enteric nervous system …
Authors
West C; Stanisz A; Bienenstock J; Barbut D; Zasloff M; Kunze WA
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 1, No. suppl_2, pp. 421–421
Publisher
Oxford University Press (OUP)
Publication Date
March 1, 2018
DOI
10.1093/jcag/gwy009.293
ISSN
2515-2084