A20 GUT MICROBIOTA-DIET INTERACTION ALTER INTESTINAL MAST CELL NUMBERS AND DISTRIBUTION IN THE HUMANIZED IBS MOUSE MODEL

Growing evidence suggests that immune activation and gut microbiota are involved in the pathophysiology of IBS. We have recently demonstrated that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) improved symptoms in IBS patients and this was associated with lower urinary histamine and changes in the microbiota composition. A high FODMAP diet in germ-free mice colonized with IBS patient microbiome …