Journal article
Proteomic changes in the rat brain induced by homogenous irradiation and by the bystander effect resulting from high energy synchrotron X-ray microbeams
Abstract
PURPOSE: To further evaluate the use of microbeam irradiation (MBI) as a potential means of non-invasive brain tumor treatment by investigating the induction of a bystander effect in non-irradiated tissue.
METHODS: Adult rats were irradiated with 35 or 350 Gy at the European Synchotron Research Facility (ESRF), using homogenous (broad beam) irradiation (HI) or a high energy microbeam delivered to the right brain hemisphere only. The proteome of …
Authors
Smith RW; Wang J; Schültke E; Seymour CB; Bräuer-Krisch E; Laissue JA; Blattmann H; Mothersill CE
Journal
International Journal of Radiation Biology, Vol. 89, No. 2, pp. 118–127
Publisher
Taylor & Francis
Publication Date
2 2013
DOI
10.3109/09553002.2013.732252
ISSN
0955-3002
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsApoptosisBrainBrain NeoplasmsBystander EffectElectrophoresis, Gel, Two-DimensionalGlial Fibrillary Acidic ProteinHeat-Shock ProteinsMaleMolecular Sequence DataNeoplasms, Radiation-InducedNerve Tissue ProteinsOxidative StressProhibitinsProteomeProteomicsRatsRats, WistarRepressor ProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSynchrotronsTriose-Phosphate IsomeraseTubulin