Journal article
When does the use of individual patient data in network meta-analysis make a difference? A simulation study
Abstract
BackgroundThe use of individual patient data (IPD) in network meta-analyses (NMA) is rapidly growing. This study aimed to determine, through simulations, the impact of select factors on the validity and precision of NMA estimates when combining IPD and aggregate data (AgD) relative to using AgD only.MethodsThree analysis strategies were compared via simulations: 1) AgD NMA without adjustments (AgD-NMA); 2) AgD NMA with meta-regression …
Authors
Kanters S; Karim ME; Thorlund K; Anis A; Bansback N
Journal
BMC Medical Research Methodology, Vol. 21, No. 1,
Publisher
Springer Nature
Publication Date
12 2021
DOI
10.1186/s12874-020-01198-2
ISSN
1471-2288