Journal article
Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study
Abstract
Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 and reinforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries. Functional analysis proposed …
Authors
Ortiz-Fernández L; Saruhan-Direskeneli G; Alibaz-Oner F; Kaymaz-Tahra S; Coit P; Kong X; Kiprianos AP; Maughan RT; Aydin SZ; Aksu K
Journal
American Journal of Human Genetics, Vol. 108, No. 1, pp. 84–99
Publisher
Elsevier
Publication Date
January 2021
DOI
10.1016/j.ajhg.2020.11.014
ISSN
0002-9297