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Clinical Impact of Pretreatment Human...
Journal article

Clinical Impact of Pretreatment Human Immunodeficiency Virus Drug Resistance in People Initiating Nonnucleoside Reverse Transcriptase Inhibitor–Containing Antiretroviral Therapy: A Systematic Review and Meta-analysis

Abstract

BACKGROUND: Increased access to antiretroviral therapy (ART) has resulted in rising levels of pretreatment human immunodeficiency virus drug resistance (PDR). This is the first systematic review and meta-analysis to assess the impact of PDR on treatment outcomes among people initiating nonnucleoside reverse transcriptase inhibitor (NNRTI)-based ART, including the combination of efavirenz (EFV), tenofovir (TDF), and lamivudine or emtricitabine …

Authors

Bertagnolio S; Hermans L; Jordan MR; Avila-Rios S; Iwuji C; Derache A; Delaporte E; Wensing A; Aves T; Borhan ASM

Journal

Journal of Infectious Diseases, Vol. 224, No. 3, pp. 377–388

Publisher

Oxford University Press (OUP)

Publication Date

August 2, 2021

DOI

10.1093/infdis/jiaa683

ISSN

0022-1899