Journal article
Efficient Synthesis of Cannabigerol, Grifolin, and Piperogalin via Alumina-Promoted Allylation
Abstract
The synthesis of three phenolic natural products has been accomplished with unprecedented efficiency using a new alumina-promoted regioselective aromatic allylation reaction. Cannabigerol and grifolin were prepared in one step from the inexpensive 5-alkyl-resorcinols olivetol and orcinol. Piperogalin was synthesized, for the first time, via two sequential allylations of orcinol with geraniol and prenol.
Authors
Jentsch NG; Zhang X; Magolan J
Journal
Journal of Natural Products, Vol. 83, No. 9, pp. 2587–2591
Publisher
American Chemical Society (ACS)
Publication Date
September 25, 2020
DOI
10.1021/acs.jnatprod.0c00131
ISSN
0163-3864