Journal article
Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials
Abstract
PurposeMotivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastrointestinal bleeding prophylaxis in critically ill patients.MethodsWe searched for randomized controlled trials that examined the …
Authors
Wang Y; Ge L; Ye Z; Siemieniuk RA; Reintam Blaser A; Wang X; Perner A; Møller MH; Alhazzani W; Cook D
Journal
Intensive Care Medicine, Vol. 46, No. 11, pp. 1987–2000
Publisher
Springer Nature
Publication Date
11 2020
DOI
10.1007/s00134-020-06209-w
ISSN
0342-4642