Journal article
A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. The paralogous transcriptional cofactors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ, also called WWTR1), the main downstream effectors of the Hippo signal transduction pathway, are emerging as pivotal determinants of malignancy in lung cancer. Traditionally, studies have tended to consider YAP and TAZ as functionally redundant …
Authors
Shreberk-Shaked M; Dassa B; Sinha S; Di Agostino S; Azuri I; Mukherjee S; Aylon Y; Blandino G; Ruppin E; Oren M
Journal
Cancer Research, Vol. 80, No. 19, pp. 4145–4157
Publisher
American Association for Cancer Research (AACR)
Publication Date
October 1, 2020
DOI
10.1158/0008-5472.can-20-0125
ISSN
0008-5472
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingCarcinoma, Non-Small-Cell LungCell CycleCell Line, TumorCell MovementChromatinGene Expression Regulation, NeoplasticHumansLung NeoplasmsPaclitaxelTrans-ActivatorsTranscription FactorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsYAP-Signaling Proteins