Journal article
A randomized controlled trial of the effects of a prudent diet on cardiovascular risk factors, gene expression, and DNA methylation - the Diet and Genetic Intervention (DIGEST) Pilot study
Abstract
BackgroundRisk of cardiovascular disease (CVD) can be increased by single-nucleotide polymorphisms (SNPs) in the 9p21 region of the genome. However, observational studies have shown that the deleterious effect of 9p21 SNPs on CVD might be offset by consuming a diet rich in fresh fruits and vegetables. This association may be driven by diet-influenced modifications in epigenetic and gene expression profiles. In this pilot study, we aimed to: i. …
Authors
Zulyniak MA; de Souza RJ; Mente A; Kandasamy S; Nundy M; Desai D; Raman K; Hasso R; Pare G; Beyene J
Journal
BMC Nutrition, Vol. 2, No. 1,
Publisher
Springer Nature
Publication Date
December 2016
DOI
10.1186/s40795-016-0074-6
ISSN
2055-0928