Combination of analyte protectants and sandwich injection to compensate for matrix effect of pesticides residue in GC–MS/MS

Matrix effect (ME) in gas chromatography (GC) is usually due to undesired interactions with active sites in the inlet and column which can lead to analyte losses and/or peak tailing. Analyte protectants (APs) are compounds added individually or in combination to interact with the active sites and minimize errors related to ME. However, the current Aps mixtures/introducing approach cannot sufficiently compensate for ME in all cases. In this …