Journal article
Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner
Abstract
Renal dysplasia, the major cause of childhood renal failure, is characterized by defective branching morphogenesis and nephrogenesis. Beta-catenin, a transcription factor and cell adhesion molecule, is markedly increased in the nucleus of kidney cells in human renal dysplasia and contributes to its pathogenesis by altering target genes that are essential for kidney development. Quercetin, a naturally occurring flavonoid, reduces nuclear …
Authors
Cunanan J; Deacon E; Cunanan K; Yang Z; Ask A; Morikawa L; Todorova E; Bridgewater D
Journal
PLOS ONE, Vol. 15, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0234375
ISSN
1932-6203