Journal article
The contact activation system as a potential therapeutic target in patients with COVID‐19
Abstract
Coronavirus disease 2019 (COVID-19) is predicted to overwhelm health care capacity in the United States and worldwide, and, as such, interventions that could prevent clinical decompensation and respiratory compromise in infected patients are desperately needed. Excessive cytokine release and activation of coagulation appear to be key drivers of COVID-19 pneumonia and associated mortality. Contact activation has been linked to pathologic …
Authors
Shatzel JJ; DeLoughery EP; Lorentz CU; Tucker EI; Aslan JE; Hinds MT; Gailani D; Weitz JI; McCarty OJT; Gruber A
Journal
Research and Practice in Thrombosis and Haemostasis, Vol. 4, No. 4,
Publisher
Elsevier
Publication Date
May 2020
DOI
10.1002/rth2.12349
ISSN
2475-0379