Journal article
IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut
Abstract
Enterochromaffin (EC) cells in the gastrointestinal (GI) mucosa are the main source of serotonin (5-hydroxytryptamine (5-HT)) in the body. 5-HT is implicated in the pathophysiology of many GI disorders including functional and inflammatory bowel disorders. Herein we studied the role of interleukin 13 (IL-13) in EC cell biology by utilizing IL-13-deficient (IL-13-/-) mice and BON cells (a model for human EC cells). The numbers of EC cells and …
Authors
Manocha M; Shajib MS; Rahman MM; Wang H; Rengasamy P; Bogunovic M; Jordana M; Mayer L; Khan WI
Journal
Mucosal Immunology, Vol. 6, No. 1, pp. 146–155
Publisher
Elsevier
Publication Date
1 2013
DOI
10.1038/mi.2012.58
ISSN
1933-0219