Journal article
A novel inhibitor of Chlamydophila pneumoniae protein kinase D (PknD) inhibits phosphorylation of CdsD and suppresses bacterial replication
Abstract
BackgroundWe have shown previously that Chlamydophila pneumoniae contains a dual-specific Ser/Thr protein kinase that phosphorylates CdsD, a structural component of the type III secretion apparatus. To further study the role of PknD in growth and development we sought to identify a PknD inhibitor to determine whether PknD activity is required for replication.ResultsUsing an in vitro kinase assay we screened 80 known eukaryotic protein kinase …
Authors
Johnson DL; Stone CB; Bulir DC; Coombes BK; Mahony JB
Journal
BMC Microbiology, Vol. 9, No. 1,
Publisher
Springer Nature
Publication Date
12 2009
DOI
10.1186/1471-2180-9-218
ISSN
1471-2180