Exercise responses after cardiac transplantation in mitochondrial myopathy

Since the first description by Luft et al1 in 1962, mitochondrial myopathy has become an increasingly recognized cause of neuromuscular disease. A wide variety of clinical syndromes has been described in patients with this disorder. 2 Although many appear to be restricted to skeletal muscle, other highly oxidative organs including the central nervous system, kidney, liver and heart have been affected in some patients with multisystem …