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Transforming growth factor β-induced peritoneal...
Journal article

Transforming growth factor β-induced peritoneal fibrosis is mouse strain dependent*

Abstract

BACKGROUND: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis. The etiology is unclear, but genetic predisposition may be a contributing factor. We used adenovirus-mediated gene transfer of transforming growth factor (TGF) β1 to the peritoneum in four genetically distinct laboratory mouse strains to assess differences in fibrogenic response. METHODS: Mice from four genetic backgrounds …

Authors

Margetts PJ; Hoff C; Liu L; Korstanje R; Walkin L; Summers A; Herrick S; Brenchley P

Journal

Nephrology Dialysis Transplantation, Vol. 28, No. 8, pp. 2015–2027

Publisher

Oxford University Press (OUP)

Publication Date

August 1, 2013

DOI

10.1093/ndt/gfs289

ISSN

0931-0509