Prostanoids

In asthmatic patients, it is likely that PGD2 and TXA2 are involved in causing acute bronchoconstriction after stimuli such as inhaled allergen in asthmatic patients. PGD2 also promotes the chemotaxis of eosinophils and Th2 cells, as well as the release of Th2 cytokines through stimulation of CRTH2. Also, there is evidence that inhibitory prostaglandins are released by asthmatic airways, which reduces bronchoconstrictor responses to stimuli …